Evaluation of Presence and Activity of Three Different Enzymes in Crevicular Fluid from Dental Implants

NTRODUCTION With the advancement in the frequency of use of dental implants for rehabilitation, there has been simultaneous increase in the capability of the clinicians in relation to the effective restoration of the dentition of the patients. From time to time, various dental implant systems have been introduced from time to time for increasing the prognosis and outcome of dental implant procedures. On the basis of chronological categories as early failures, distinguishing if the dental implants can be done within few weeks to few months of dental implants. For monitoring the conditions of endosseous dental implants, monitoring of the clinical periodontal parameters have been widely used in the literature. However, precise significance of these clinical parameters (periodontal bleeding, periodontal probing etc) in relation to the monitoring of outcome of dental implants is still unclear. Gingival crevicular fluid (GCF) has been studies a number of times in the past literature for monitoring the periodontal activities. Aspartate aminotransferase (AST) is the enzyme which under physiologic conditions is confined to cytoplasm but in case of cell death, is released into the extracellular environment. Two such enzymes associated with disuse destruction due to periodontal pathologies are AST and alkaline phosphatise (AP). Increased levels of serum cathepsin K (CK) has been found to be associated with chronic inflammatory processes. Hence; the present study was undertaken to evaluate the activity of AST, AP and CK in Peri-implant crevicular Fluid (PIF) obtained from healthy and pathologic tissue associated with endosseous dental implants.